Longevity in the News: Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors

October 14, 2022

Age vs. genetics: Which is more important for determining how we age?

A new study from University of California, Berkeley suggests that in many cases, age plays a more important role than genetics in determining which genes in our bodies are turned on or off. The level at which genes are expressed – that is, ratcheted up or down in activity – determines everything from our hormone levels and metabolism to the mobilization of enzymes that repair the body.

A granular bioink could bring 3D-printed organs to life

In a new paper published in the journal Small, Penn State scientists hope to solve the organ transplant issue with an alternative material – nanoengineered granular hydrogel bioink consisting of self-assembling nanoparticles and hydrogel microparticles or microgels.

A new blood test detects over 50 types of cancer

Galleri is a new blood test that has the ability to detect more than 50 types of cancer through a single blood draw. Forty-five of those cancer types don’t currently have another recommended screening. Experts say Galleri has the opportunity to revolutionize cancer screening, potentially leading to reductions in the human and economic toll of cancer.

Mitochondrial transplant therapy shown to make immune systems 30 years younger

Mitrix Bio, a Californian longevity biotech start-up, is testing a new therapy to boost immune system strength using tiny particles called “mitlets” that contain mitochondria. The company says that injections of mitlets in animal models appear to reverse immune weakness, making old immune systems temporarily young again.

Eye on the Future: Making Technology That Supports Health & Fitness

Computed Tomography Angiography (CTA) is a new development in super fast imaging using a 16 slice CT scanner – allowing for “non-invasive imaging” which can provide early detection for conditions such as aortic dissection (tearing of wall of aorta).

Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors

In a paper recently published in Nature Nanotechnology, Siegwart and his team developed a dual approach using LNPs equipped with tools that allow them to access and modify the tumor by packaging the LNPs with a CRISPR-Cas9 system that genetically modified and disrupted PD-L1 gene expression. To grant the CRISPR system tumor access, the LNP also included siRNA that targeted focal adhesion kinase (FAK), which diminished the density of extracellular tumors.

Revolutionary 99% Accurate AI Scanner Could Eliminate Cancer Treatments

Breast cancer patients may be able to avoid chemotherapy thanks to a new AI scanner that can accurately predict whether the cancer is likely to return. The technology, called Digistain, is not yet used on the NHS but has the potential to save thousands of pounds per patient and free up hospital resources.

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