The researchers found that parabiosis had largely expected results, including beneficial effects on gene expression networks and an improvement of intercellular communication in order to encourage neurogenesis. The paper highlighted the youth-promoting effects of parabiosis on the endothelial cells, as well as its potential to impact vascular structure and health.

Researchers Delay Aging By Editing Genes To Remove Glyceraldehyde From Blood

UVA researchers have identified a potential approach to delay aging by reducing the toxic effects of glycerol and glyceraldehyde. The new findings discovered an enzyme, alcohol dehydrogenase, to activate an anti-aging process, AMAR (Alcohol and aldehyde-dehydrogenase Mediated Anti-aging Response). 

Rejuvenating stem cells could slow Duchenne muscular dystrophy

Researchers have linked Duchenne muscular dystrophy (DMD) to a loss of regenerative capacity of muscle stem cells. Findings published in Science Translational Medicine suggest that boosting the regenerative capacity could delay/prevent DMD progression.

New Understanding of Aging Processes in the Brain Unearths Target for Therapies

Research from TBSI showed a link between increased presence of immune cells and age-related neurological diseases. This study focused on microglia, specialized immune cells that support nerve cells and clear debris in the brain and spinal cord.

Sam Altman invested $180 million into a company trying to delay death

In mid-2022, Retro Biosciences emerged from stealth mode announcing it had secured $180 million to extend the average human lifespan. Sam Altman, CEO of OpenAI and Y Combinator startup guru, funded the entire sum. Altman’s investments are in three areas: Artificial Intelligence (Open AI), Energy (Helion Energy) and anti-aging biotech (Retro). Researchers studied young blood experiments to rejuvenate old mice, which resulted in Altman funding Betts-LaCroix for further research at Retro.

Designer Drug Alleviates Alzheimer’s in Mouse Model

A novel approach called targeted protein degradation (TPD) is used to selectively eliminate disease-causing proteins. The newly developed TPD molecule PRZ-18002 was found to be highly selective and effective at decreasing p-p38 MAPK levels, leading to decreased inflammation and increased cognition. 

Metformin and Rapamycin Rejuvenate Stem Cells in Mice

Aging is associated with an increased risk for gastrointestinal problems and colorectal cancer. Intestinal stem cells continuously divide to generate several types of progenitor cells, regulated by the Lgr5 gene and WNT signaling pathway. Upon aging, Lgr5 expression decreases and metabolic pathways are disturbed, reducing the proliferative capacity of the cells.