A new study published in Nature Communications demonstrates the power of AI to provide insights into the nature of aging, resilience and future medical interventions for age-related diseases.

Using gene editing to fight deadly genetic diseases

David Liu, Richard Merkin Professor and Director of the Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard and Thomas Dudley Cabot Professor of the Natural Sciences at Harvard, spoke about cutting-edge gene editing techniques that hold enormous promise for tackling devastating diseases such as sickle cell disease, Huntington’s disease, and heart disease.

Finding molecular secrets hidden in premature aging diseases and cancer using mahine learning

Researchers from Insilico Medicine, the University of Copenhagen, and the University of Chicago collaborated to find new ways to treat age-related diseases using an AI-driven target and drug discovery pipeline.

Smallest ever mobile lifeform created – opening the door to disease-curing microrobots

Scientists in Japan have created the smallest ever mobile lifeform by inserting a tiny genome into an empty cell. The small, spherical synthetic bacteria can grow and divide. Re-engineered syn3 changed from its normal spherical shape into a spiraling helix, which was able to swim by reversing the helix’s direction just like Spiroplasma.

BioAge announces positive results for clinical trial reversing muscle aging

The drug was well tolerated in the study, consistent with prior phase 1 trials conducted by Amgen showing that oral or intravenous BGE_105 was safe and well tolerated in 198 subjects. BioAge plans to proceed with a Phase 2 trial of BGE_105 to prevent adverse outcomes in older patients under mechanical ventilation in the intensive care unit (ICU).

Longevity Drug Rapamycin Shown to Fight Infection

The researchers found that dietary restriction slightly but significantly increased the risk of pathogen infection, while rapamycin treatment significantly decreased it, particularly in secondary infections.

Activate the Okinawan ‘longevity gene’ with diet

Studies of humans who live to 100 years old have found that many share an unusual version of the FOX03 gene, which is essential for longevity. Doctor Bradley Willcox suggests that there are ways this gene can be activated through diet, including eating certain foods and consuming jasmine tea and turmeric.

Alzheimer’s: How brain immune cells can slow down progression

Scientists have long debated whether the brain’s immune cells, known as microglia, have a protective or a detrimental role in the disease. A new study has added evidence that they protect the brain in the early stages of the disease before symptoms develop.

Unlocking the Potential of Small Molecules: How They Could Revolutionize Regenerative Medicine and Cancer Research

Small molecules are cell-permeable organic compounds with low molecular weights that are chemically produced, as opposed to larger proteins which often occur naturally. They play a crucial role in an affordable cell culture toolkit that can be used to maintain, reprogram, and differentiate cells. 

INSPIRE launched to develop inhaled gene therapy for the treatment of lung cancer

OmniSpirant Limited and EVerZom have launched INSPIRE, a €12.8 million ($13.4 million) lung cancer project funded by Horizon Europe in an effort to create a regenerative gene therapy as a transformative new treatment for lung cancer. 

New Potential for Reversing Aging: Scientists Discover Changes in Aging Stem Cells

Scientists have developed a method to identify aging muscle stem cells based on their chromatin signature. If the chromatin signature of an aged cell can be restored to that of a young cell, the process of cellular aging may be slowed or even reversed.